The process, which is available with the full text of this article at NEJM.org, was approved by the institutional review table at each middle, and written informed consent was obtained from all individuals. The trial sponsor gathered and maintained all the data. A central committee whose users were unaware of the study-group assignments adjudicated the outcomes of most baseline lung-imaging lab tests and all suspected final result events. An unbiased data and basic safety monitoring panel periodically reviewed the analysis outcomes.The male condom is placed on the male organ when it becomes erect. It really is unrolled all the way to the bottom of the penis while holding the end of the condom to keep some extra room at the end. This creates a space for semen after ejaculation and helps it be not as likely that the condom will break. After the male ejaculates, the condom ought to be held by him at the base of the penis as he pulls out from the vagina. He must do this as the penis is still erect to avoid the condom from slipping off when he gets smooth.