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The research conducted by Dr. Paterson and colleagues, as well as research conducted at additional institutions, shows that this antigen may have utility in treating additional tumor types aswell. ISG15 is Advaxis’ first proprietary antigen, stated Dr. John Rothman, Executive Vice President, Science & Operations.. Advaxis licenses ISG15 tumor antigen from University of Pennsylvania Advaxis, Inc., , a leader in developing another era of immunotherapies for cancers and infectious illnesses, has exclusively licensed the use of antigen ISG15 in Advaxis’ Lm-LLO based immunotherapies from the University of Pennsylvania. This intellectual property or home resulted from research carried out in Dr.