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AbbVie’s venetoclax granted FDA Breakthrough Therapy Designation for CLL sufferers with 17p deletion AbbVie today announced its investigational medicine venetoclax, an inhibitor of the B-cell lymphoma-2 protein that is being developed in partnership with Genentech and Roche, has been granted Breakthrough Therapy Designation by the FDA for the treating chronic lymphocytic leukemia in previously treated sufferers with the 17p deletion genetic mutation.