A practical guideline to contraception. Other contraceptive methods will be discussed in subsequent articles. Correction A correction for this article was published in the August 2013 problem of Medicine Today. The full text PDF of this article has been corrected. Combined hormonal contraceptives , that have an oestrogen and a progestogen, can be found as combined contraceptive pills and the vaginal band. The advantages of CHCs include helpful effects on acne, reduction in menstrual pain and bleeding and the ability to manipulate menstrual cycles. CHC use is connected with some serious dangers but the absolute risk can be low for some women of reproductive age group.Other end points included PASI 50, PASI 75, PASI 90, PASI 100, and the response of 0 or 1 on the modified investigator’s global assessment until week 52 and a DLQI score of 0 or 1 at weeks 12 and 52. Statistical Analysis In each study, the analyses of the efficacy end factors included all the sufferers who underwent randomization based on the treatment assigned at randomization. Closed testing procedures19 were used to evaluate the analysis hypotheses. Under these methods, hypotheses regarding the 300-mg and 150-mg doses of secukinumab were evaluated independently, each at the 0.025 significance level, to control the family-wise error rates . Missing values for the PASI score and the score on the altered investigator’s global assessment had been conservatively imputed as non-responses, regardless of the reason behind the missing data.