Harkness’ team saw that the youths with a brief history of maltreatment experienced a total blunting of the endocrine response to stress. These findings suggest that the normal operation of the strain response program can breakdown in severely depressed adolescents. These results are essential because they present that environmental tension in childhood changes the function of the brain in ways that could cause and/or maintain severe psychiatric disorders such as depression.Future studies are warranted to investigate additional risk elements that may link diabetes and chronic diseases, to review non-Western populations,37 also to explain associations observed between very low glucose levels and vascular loss of life in people without diabetes. In conclusion, in addition to vascular disease, diabetes is normally associated with considerable premature death from several cancers, infectious diseases, exterior causes, intentional self-harm, and degenerative disorders, independent of main risk factors. These results highlight the necessity to better understand and prevent the multisystem implications of diabetes.. Noise and Polluting of the environment has severe implications on heart health Cardiovascular diseases , including heart stroke and disease, are the zero 1 killer world-wide and in Europe, where the death is caused by them of over 10 000 people daily, i.e.