The Global Polio Eradication Initiative is certainly spearheaded by national governments, WHO, Rotary International, the UNICEF and CDC. Since the start of the GPEI in 1988, the incidence of polio has been reduced by a lot more than 99 percent. In 1988, a lot more than 350 000 children were paralyzed every year in a lot more than 125 endemic countries. Only four countries remain endemic: Nigeria, India, Afghanistan and Pakistan.. 72 million children to be immunized against polio throughout 15 African countries More than 72 million kids to be immunized across 15 countries to tackle remaining risksThis full week, Africa seizes an unprecedented possibility to operate a vehicle out polio when 15 countries over the continent launch a synchronized mass immunization advertising campaign to reach 72 million children, capitalizing on gains made this season.Statistical Analysis The original sample size of 2500 patients was calculated based on an assumed average follow-up of three years, around 3-year rate of recurrent stroke of 21 percent, and a 25 percent relative reduction in the risk of stroke in the group receiving dual antiplatelet therapy , with a type I error of 0.05 and a sort II error of 0.10. The sample size was reestimated midway through the trial to assess power based on the observed overall event price at that time, with the effect that the sample size was increased from 2500 to 3000 patients, with a 1-calendar year extension of follow-up.20 The primary analyses were based on standard time-to-event methods, with each treatment group assessed by using the log-rank test; Cox proportional-hazards versions were used to calculate hazard ratios.