These features, in combination with the presence of morphologic and nuclear abnormalities in megakaryocytes, indicate that GFI1BTr impacts the terminal maturation of megakaryocytes. GFI1B silencing and Gfi1b ablation research show that the proteins is fundamental to the advancement of several blood-cell lineages.15,17-20 In the affected family we studied, the current presence of GFI1BTr was connected with major abnormalities only in the megakaryocytic lineage. The mutation in the gray platelet syndrome introduces a stop codon that results in a truncated GFI1B protein.There’s been a renaissance in AIDS vaccines, Seth Berkley, president of the International Helps Vaccine Initiative, said . A related Reuters factbox notes some latest AIDS vaccine developments . Specialists are optimistic that breakthroughs in HIV vaccine research are possible if indeed they work together, Inter Press Support writes in an content examining the quest to produce an effective AIDS vaccine. Relating to IPS, the Global HIV Vaccine Business, a collaborative group made up of more than 400 scientists from all over the world, in September plans to release a strategic plan. The article also discusses various other prevention techniques and outlines why a vaccine is so desirable .S.