One bottom line reported by the experts is that diabetes could be recognized as the last step of chronic pancreatitis with the brand new developing ideas of pathogenesis and that the elevation of Ca 19-9 is because of chronic pancreatitis and not to pancreatic malignancy. As a remedy to the problem they recommend using higher cut-off ideals of Ca 19-9 in diabetics to differentiate benign and malignant pancreatic disease.Eligible individuals were randomly assigned at a 1:1 ratio to receive treatment with or without cetuximab. Randomization was performed centrally by a minimization technique with stratification according to serum lactate dehydrogenase level , earlier adjuvant chemotherapy , number of affected organs , and treatment middle. An independent data and protection monitoring committee evaluated all severe adverse events. All patients provided written informed consent before study entry. Bevacizumab was donated by Roche, and cetuximab was donated by Merck Serono. The sponsors of the analysis were knowledgeable of the outcomes of the analysis but did not donate to any stage of the analysis design; the collection, evaluation, and interpretation of the data; or the writing of the manuscript.5 mg of bevacizumab per kilogram of bodyweight, given intravenously on day 1.