But clinical trials are underway to observe whether vitamin D supplements might help slow MS progression, said LaRocca, who was simply not involved in the current study. Until those trial email address details are in, it’s too soon to make any specific vitamin D suggestions, according to LaRocca. But, he added, since adequate supplement D is important for overall health, people who have MS could speak to their doctors about going for a supplement. ‘They might be advised to have their vitamin D level tested first,’ LaRocca said. Multiple sclerosis involves an abnormal immune system attack about the protective sheath surrounding nerve fibers in the brain and spine.Participants were followed up personally or by telephone at 28 times and at 3 months by trained local staff who were unaware of the group assignments. Individuals who did not have the assigned treatment or who didn’t adhere to the protocol were followed up in full, and their data were included in the analyses based on the intention-to-deal with principle. Outcome Measures The primary outcome measure was the proportion of participants with a poor outcome, defined as death or major disability. Main disability was thought as a score of 3 to 5 5 on the modified Rankin scale at 3 months after randomization. Ratings on the modified Rankin scale range between 0 to 6, with a score of 0 indicating no symptoms; a score of 5 indicating severe disability, confinement to bed, or incontinence; and a score of 6 indicating loss of life.15 However, during the trial, ordinal methods to the analysis of the modified Rankin scores gained acceptance in stroke trials.