Adjunctive drugs hasten sedation in the emergency department By Eleanor McDermid.

The most common events had been oxygen desaturation, airway obstruction, and hypotension. Taylor et al obtained electrocardiograms for 211 patients in all. Droperidol has previously been linked to an elevated risk for an extended QT torsades and interval de pointes, however the united team found no evidence to support this; two individuals experienced a QTc interval of 500 ms or even more, and neither was in the droperidol group. Licensed from medwireNews with permission from Springer Healthcare Ltd. All rights reserved. Neither of these parties endorse or recommend any commercial products, services, or equipment.. Adjunctive drugs hasten sedation in the emergency department By Eleanor McDermid, Senior medwireNews Reporter Adding intravenous droperidol or olanzapine to midazolam shortens the time to adequate sedation in acutely agitated patients in the emergency department , show results from a randomized controlled trial.Enrollment was planned to occur over a 3-year period initially, with an additional 1 year of follow-up, but due to slower-than-anticipated enrollment, the enrollment period was extended to 4.5 years, with 6 additional months of follow-up. An unbiased data and safety monitoring table reviewed the progress of the study for safety and efficacy regularly. Five prepared interim analyses were performed before the final analysis to provide a guideline as to whether the study should be stopped early due to efficacy or futility.22 Outcomes Study Population A complete of 832 patients provided written informed consent, and 649 were randomly assigned to receive extended-release dipyridamole plus aspirin or placebo .